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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TDRKH
All Species:
2.73
Human Site:
T461
Identified Species:
6
UniProt:
Q9Y2W6
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2W6
NP_001077434.1
606
67025
T461
K
I
S
S
Y
V
Q
T
G
I
S
T
W
P
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108076
573
62636
A434
Q
A
I
E
C
S
L
A
R
I
A
P
S
G
D
Dog
Lupus familis
XP_851426
551
60647
F416
S
D
F
L
S
L
P
F
Q
A
I
E
C
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q80VL1
560
62116
A425
E
C
S
L
A
R
I
A
P
T
G
E
E
W
E
Rat
Rattus norvegicus
XP_227438
560
61993
A425
E
C
S
L
A
R
I
A
P
S
G
E
E
W
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514669
319
34334
L184
G
Q
W
E
E
A
A
L
D
E
F
E
R
L
T
Chicken
Gallus gallus
XP_423400
665
71440
A434
K
I
S
S
Y
T
Q
A
G
L
C
T
W
P
R
Frog
Xenopus laevis
NP_001089292
718
79433
P460
K
I
S
S
F
P
S
P
G
V
S
C
F
Q
V
Zebra Danio
Brachydanio rerio
NP_001014377
573
63662
S432
S
M
R
S
D
F
L
S
L
P
F
Q
A
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608657
576
63805
K440
T
A
V
S
A
A
A
K
E
G
T
P
L
P
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785759
489
55090
S354
D
S
E
A
T
P
K
S
S
V
C
T
L
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
85.3
82.6
N.A.
84.8
85.8
N.A.
29.8
39
36.3
38.2
N.A.
23.9
N.A.
N.A.
33.1
Protein Similarity:
100
N.A.
87.1
85.9
N.A.
88.1
88.6
N.A.
39.1
53.3
54.8
57.4
N.A.
42.5
N.A.
N.A.
49.6
P-Site Identity:
100
N.A.
6.6
0
N.A.
6.6
6.6
N.A.
0
66.6
40
6.6
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
20
6.6
N.A.
20
20
N.A.
0
80
60
26.6
N.A.
20
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
10
28
19
19
37
0
10
10
0
10
0
0
% A
% Cys:
0
19
0
0
10
0
0
0
0
0
19
10
10
0
0
% C
% Asp:
10
10
0
0
10
0
0
0
10
0
0
0
0
0
19
% D
% Glu:
19
0
10
19
10
0
0
0
10
10
0
37
19
0
28
% E
% Phe:
0
0
10
0
10
10
0
10
0
0
19
0
10
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
28
10
19
0
0
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
28
10
0
0
0
19
0
0
19
10
0
0
10
0
% I
% Lys:
28
0
0
0
0
0
10
10
0
0
0
0
0
0
10
% K
% Leu:
0
0
0
28
0
10
19
10
10
10
0
0
19
10
10
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
19
10
10
19
10
0
19
0
28
0
% P
% Gln:
10
10
0
0
0
0
19
0
10
0
0
10
0
10
0
% Q
% Arg:
0
0
10
0
0
19
0
0
10
0
0
0
10
10
10
% R
% Ser:
19
10
46
46
10
10
10
19
10
10
19
0
10
10
0
% S
% Thr:
10
0
0
0
10
10
0
10
0
10
10
28
0
0
10
% T
% Val:
0
0
10
0
0
10
0
0
0
19
0
0
0
0
10
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
19
19
0
% W
% Tyr:
0
0
0
0
19
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _